研究成員

王宗興 (Wang, Tsung-Shing Andrew)

台灣大學化學系副教授


電話:(02)3366-8711
傳真:(02)3366-8670
E-MAIL:wangts@ntu.edu.tw
歷年論文與研究計畫:臺大學術典藏

研究領域

  • 新抗細菌藥物設計及開發
  • 細菌致病因子
  • 宿主與病原菌交互作用
  • 功能性生物試劑設計及開發



    簡歷

  • 2001 年大學化學學士
  • 2003-2004 年臺灣大學化學系研究助理
  • 2011 年美國哈佛大學化學博士
  • 2011-2013 年美國斯克瑞普斯研究所博士後研究員
  • 2013-2018任臺灣大學化學系助理教授
  • 2018年迄今任臺灣大學化學系副教授



    榮譽

  • 李遠哲化學獎學金 (1997-2001)
  • 國科會大專學生研究創作獎 (2001)
  • 台灣大學理學院院長獎 (2001)
  • 國立臺灣大學教學優良獎(2016、2017、2020)



    代表著作

    1. Oman, T. J.; Lupoli, T. J.; Wang, T.-S.; Kahne, D.; Walker, S.; van der Donk, W. A. “Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry” J. Am. Chem. Soc. 2011, J. Am. Chem. Soc. 2011, 133, 17544–17547.
    2. Lupoli, T. J.; Tsukamoto, H.; Doud, E.; Wang, T.-S.; Walker, S.; Kahne, D. “Transpeptidase- Mediated Incorporation of D-Amino Acids” J. Am. Chem. Soc. 2011, 133, 10748–10751.
    3. Wang, T.-S.; Lupoli, T. J.; Sumida, Y.; Tsukamoto, H.; Wu, Y.; Rebets, Y.; Kahne, D.; Walker, S. &ldquiPrimer Preactiviation of Peptidoglycan Polymerases” J. Am. Chem. Soc. 2011, 133, 8528–8530.
    4. Gampe, C. M.; Tsukamoto, H.; Wang, T.-S.; Walker, S.; Kahne, D.“Modular Synthesis of Diphospholipid Oligosaccharide Fragments of the Bacterial Cell Wall and Their Use to Study the Mechanism of Moenomycin and Other Antibiotics” Tetrahedron 2011, 67, 9771–9778.
    5. Fuse, S.; Tsukamoto, H.; Yuan, Y.; Wang T.-S.; Zhang, Y.; Bolla, M.; Walker, S.; Sliz, P.; Kahne, D. “Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin” ACS Chem. Biol. 2010, 5, 701–711.
    6. Perlstein, D. L.; Wang, T.-S.; Doud, E.; Kahne, D.; Walker, S. “The Role of the Substrate Lipid in Processive Glycan Polymerization by the Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2010, 132, 48–49.
    7. Lupoli, T. J.; Taniguchi, T.; Wang, T.-S.; Perlstein, D. L.; Walker, S.; Kahne, D. “Studying a Cell Division Amidase Using Defined Peptidoglycan Substrates” J. Am. Chem. Soc. 2009, 131, 18230–18231.
    8. Wang, T.-S.; Manning, S. A.; Walker, S.; Kahne, D. “Isolated Peptidoglycan Glycosyltransferases from Different Organisms Produce Different Glycan Chain Lengths” J. Am. Chem. Soc. 2008, 130, 14068–14069.
      This work was featured in NEWS OF THE WEEK, Chem. & Eng. News
    9. Arnaud, C “CELL-WALL SET POINT, BIOSYNTHESIS: Closely related bacterial enzymes make cell-wall polymers of varying lengths” Chem. & Eng. News 2008, 86, 9.
    10. Barrett, D.; Wang, T.-S.; Yuan, Y.; Zhang, Y.; Kahne, D.; Walker, S. “Analysis of Glycan Polymers Produced by Peptidoglycan Glycosyltransferases” J. Biol. Chem. 2007, 282, 31964–31971.
    11. Perlstein, D. L.; Zhang, Y.; Wang, T.-S.; Kahne, D.; Walker, S. “The Direction of Glycan Chain Elongation by Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2007, 129, 12674–12675.
    12. Zhang, Y.; Fechter, E. J.; Wang, T.-S.; Barrett, D.; Walker, S.; Kahne, D. “Synthesis of Heptaprenyl-lipid IV to Analyze Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2007, 129, 3080–3081.
    13. Li, P.-C.; Wang, T.-S.; Lee, G.-H.; Liu, Y.-H.; Wang, Y.; Chen, C.-T.; Chao, I. “Theoretical Study and X-Ray Determination of Bianthrones: Long C-C Bond Length and Preferred Gauche Conformation” J. Org. Chem. 2002, 67, 8002–8009.